منابع مشابه
Population toxicokinetics of benzene.
In assessing the distribution and metabolism of toxic compounds in the body, measurements are not always feasible for ethical or technical reasons. Computer modeling offers a reasonable alternative, but the variability and complexity of biological systems pose unique challenges in model building and adjustment. Recent tools from population pharmacokinetics, Bayesian statistical inference, and p...
متن کاملBenzene toxicokinetics in humans: exposure of bone marrow to metabolites.
A three compartment physiologically based toxicokinetic model was fitted to human data on benzene disposition. Two separate groups of model parameter derivations were obtained, depending on which data sets were being fitted. The model was then used to simulate five environmental or occupational exposures. Predicted values of the total bone marrow exposure to benzene and cumulative quantity of m...
متن کاملUrban Benzene Pollution and Population Exposure
Benzene is among the gasoline components and is airborne by vehicular traffic. It is a myelotoxic and leukaemia-inducing compound (Snyder et al., 1993; Ward et al., 1992; Vigliani and Saita, 1964). The risk level, expressed as myeloid leukaemia cases increment estimate among the population not professionally exposed to benzene, has been stated to range 3.8 to 7.5 cases every million people expo...
متن کاملToxicokinetics of Kava
Kava is traditionally consumed by South Pacific islanders as a drink and became popular in Western society as a supplement for anxiety and insomnia. Kava extracts are generally well tolerated, but reports of hepatotoxicity necessitated an international reappraisal of its safety. Hepatotoxicity can occur as an acute, severe form or a chronic, mild form. Inflammation appears to be involved in bot...
متن کاملToxicokinetics of ammonium perfluorohexanoate.
Excretion patterns and rates of ammonium perfluorohexanoate (APFHx) after administration of a single and multiple (14 days) oral dose(s) at 50 mg/kg to male and female mice and rats were examined. The test substance was [(14)C]-labeled APFHx. After a single oral administration, total excretion was rapid, with mean recoveries of over 90% of the dose at 24 hours after administration, irrespective...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1996
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.961041405